CALERIE began as the first U.S. clinical trial to investigate the impacts of sustained calorie restriction in primates. The two phases of CALERIE study concluded caloric restriction instigates weight loss, reduces risks of cardiovascular disease and chronic disease, and contributes to a significant reduction in negative effects of the aging process.
The secondary outcomes and health effects of CR ranged from improved body composition, reduced oxidative stress, increased immune function, lowered glucose levels, improved cognitive function, and long-term reduction to risks of obesity and early morbidity.
CALERIE was the first study of its kind to take an intensive behavioral approach to objectively measuring caloric restriction’s impacts on biologic effects through a randomized controlled trial.
CALERIE participants were healthy, nonobese humans of various gender and ethnic groups. Participants conformed to dietary modifications including, but not limited to, limited calorie intake, reduced portion size, specific meal plans, and low-carbohydrate diets. CALERIE participants incorporated particular behavioral strategies, group counseling sessions, and social support networks as a part of their participation in the calorie restriction group.
Researchers used the intake balance method to calculate energy intake from the difference between changes in energy stores (assessed by dual energy X-ray absorptiometry) and total energy expenditure (TEE) assessed by the doubly-labeled water method.
The full CALERIE data set is summarized and available on the Duke University’s website: https://calerie.duke.edu.
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